Journal: PLoS ONE

Article Title: Sensitivity of IFN-γ Release Assay to Detect Latent Tuberculosis Infection Is Retained in HIV-Infected Patients but Dependent on HIV/AIDS Progression

doi: 10.1371/journal.pone.0001441

Figure Lengend Snippet: Characteristics of patients included in the cohort, with a detail of those responding and those not responding to ELISPOT PHA positive control.

Article Snippet: BCG scar and gender were forced into the final logistic model. Data were analysed using STATA 7 software (StataCorp LP, USA).

Techniques: Enzyme-linked Immunospot, Control

Journal: PLoS ONE

Article Title: Sensitivity of IFN-γ Release Assay to Detect Latent Tuberculosis Infection Is Retained in HIV-Infected Patients but Dependent on HIV/AIDS Progression

doi: 10.1371/journal.pone.0001441

Figure Lengend Snippet: Analysis of the determinants of positive response to the ESAT6/CFP10 ELISPOT assay and to the TST (n = 247).

Article Snippet: BCG scar and gender were forced into the final logistic model. Data were analysed using STATA 7 software (StataCorp LP, USA).

Techniques: Enzyme-linked Immunospot, Infection

Journal: Heliyon

Article Title: Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity

doi: 10.1016/j.heliyon.2024.e32117

Figure Lengend Snippet: The demographic and clinical characteristics of the subjects.

Article Snippet: HCs were characterized by an absence of any BCG scar and radiographic signs suggestive of TB disease, as well as both a negative response to the TST (<5 mm, TB-PPD, Beijing Xiangrui Biological Products Co., Ltd.) and T-SPOT test (T-SPOT.

Techniques: Biomarker Discovery

Journal: Heliyon

Article Title: Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity

doi: 10.1016/j.heliyon.2024.e32117

Figure Lengend Snippet: The antigens with differential response to IgG antibody between BCG-vaccinated subjects and HCs.

Article Snippet: HCs were characterized by an absence of any BCG scar and radiographic signs suggestive of TB disease, as well as both a negative response to the TST (<5 mm, TB-PPD, Beijing Xiangrui Biological Products Co., Ltd.) and T-SPOT test (T-SPOT.

Techniques: Fluorescence

Journal: Heliyon

Article Title: Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity

doi: 10.1016/j.heliyon.2024.e32117

Figure Lengend Snippet: The antigens with differential response to IgM antibody between BCG-vaccinated subjects and HCs.

Article Snippet: HCs were characterized by an absence of any BCG scar and radiographic signs suggestive of TB disease, as well as both a negative response to the TST (<5 mm, TB-PPD, Beijing Xiangrui Biological Products Co., Ltd.) and T-SPOT test (T-SPOT.

Techniques: Fluorescence

Journal: Heliyon

Article Title: Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity

doi: 10.1016/j.heliyon.2024.e32117

Figure Lengend Snippet: Heatmap of antibody responses against five antigens. (A) IgG reactivity, (B) IgM reactivity. The heatmap presents the antibody responses in each individual serum from the BCG-vaccinated subjects and the HCs to each of the five antigens targeted by IgG and IgM simultaneously. Each row denotes one antigen, and each column denotes one serum sample. The color spectrum ranges from red to white to blue, indicating reactivity from high to low. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: HCs were characterized by an absence of any BCG scar and radiographic signs suggestive of TB disease, as well as both a negative response to the TST (<5 mm, TB-PPD, Beijing Xiangrui Biological Products Co., Ltd.) and T-SPOT test (T-SPOT.

Techniques:

Journal: Heliyon

Article Title: Potential biomarkers for evaluating the BCG vaccination response based on humoral immunity

doi: 10.1016/j.heliyon.2024.e32117

Figure Lengend Snippet: IgG and IgM levels against Rv0060, Rv2026c and Rv3379c in BCG-vaccinated subjects and HCs assayed by ELISA. (A) IgG levels, (B) IgM levels. Two-sided p values obtained by Mann-Whitney test, (**) p < 0.01; (***) p < 0.001; and bars, median values.

Article Snippet: HCs were characterized by an absence of any BCG scar and radiographic signs suggestive of TB disease, as well as both a negative response to the TST (<5 mm, TB-PPD, Beijing Xiangrui Biological Products Co., Ltd.) and T-SPOT test (T-SPOT.

Techniques: Enzyme-linked Immunosorbent Assay, MANN-WHITNEY